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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/10674

Title: Lateral phase separation in tense membranes
Authors: Hamada, Tsutomu
Kishimoto, Yuko
Nagasaki, Takeshi
Takagi, Masahiro
Keywords: membrane tension
phase separation
lipid membranes
phase diagram
giant vesicles
Issue Date: 2011-08-10
Publisher: Royal Society of Chemistry
Magazine name: Soft Matter
Volume: 7
Start page: 9061
End page: 9068
DOI: 10.1039/C1SM05948C
Abstract: The organization of lateral domains, called lipid rafts, in plasma membranes is essential for physiological functions, such as signaling and trafficking. In this study, we performed a systematic analysis of lateral phase separation under membrane tension. We applied osmotic pressure directed toward the outside of vesicles to induce membrane tension. Microscopic observations clarified the shifts in phase structures within bilayer membranes with change in tension and temperature. The miscibility transition temperature between one-liquid and two-liquid states was shown to increase under tension. We also observed a shift in the transition temperature between two-liquid and solid–liquid states in membranes under tension. We determined a quantitative phase diagram of phase organization with respect to the applied pressure and temperature. The results indicate that membrane tension can induce phase separation in homogeneous membranes. Our findings may provide insight into the biophysics of bilayer phase organization under tension, which is an intrinsic mechanical property of membranes.
Rights: Copyright (C) 2011 Royal Society of Chemistry. Tsutomu Hamada, Yuko Kishimoto, Takeshi Nagasaki, Masahiro Takagi, Soft Matter, 7, 2011, 9061-9068. http://dx.doi.org/10.1039/C1SM05948C - Reproduced by permission of The Royal Society of Chemistry
URI: http://hdl.handle.net/10119/10674
Material Type: author
Appears in Collections:c10-1. 雑誌掲載論文 (Journal Articles)

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