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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/10864

Title: Dynamic transformation of a cell-sized liposome containing ganglioside
Authors: Dhingra, Shruti
Morita, Masamune
Yoda, Tsuyoshi
Vestergaard, Mun’delanji C.
Hamada, Tsutomu
Takagi, Masahiro
Keywords: Ganglioside
Model membrane
Membrane dynamics
Issue Date: 2011-11
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Magazine name: 2011 International Symposium on Micro-NanoMechatronics and Human Science (MHS)
Start page: 461
End page: 465
DOI: 10.1109/MHS.2011.6102232
Abstract: It is important to understand the physicochemical mechanisms that are responsible for the morphological changes in the cell membrane in presence of various stimuli such as osmotic pressure. Role of micro domains such as lipid rafts in cellular processes are now beginning to unfold. In this study, we examined how constituent molecules affect the dynamical motion of liposome. We used cell-sized lipid vesicles to enable the direct observation of these changes. We observed the effect of GM1 ganglioside to osmotic transformation in a homogeneous and heterogeneous liposome. Interestingly it was observed that for the formation of sphero stomatocyte their exist a particular critical cut off concentration. Also in the case of heterogeneous liposome it was observed that at 10 % of GM1 almost all domains were pinched out from the vesicles, forming their own homogeneous liposome’s. This finding provides a possible mechanism of apoptosis induction by GM1. Incorporation of GM1 into membrane leads to an increase of the line tension. Thus, necessary proteins can find themselves in one common raft and start the corresponding cascade of reactions.
Rights: This is the author's version of the work. Copyright (C) 2011 IEEE. 2011 International Symposium on Micro-NanoMechatronics and Human Science (MHS), 2011, 461-465. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
URI: http://hdl.handle.net/10119/10864
Material Type: author
Appears in Collections:z1-11-1. 会議発表論文 (Conference Papers)

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