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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/12846

Title: Self-degradation of tissue adhesive based on oxidized dextran and poly-l-lysine
Authors: Matsumura, Kazuaki
Nakajima, Naoki
Sugai, Hajime
Hyon, Suong-Hyu
Keywords: biodegradation
bioadhesive
hydrogel
dextran
poly-L-lysine
Issue Date: 2014-07-06
Publisher: Elsevier
Magazine name: Carbohydrate Polymers
Volume: 113
Start page: 32
End page: 38
DOI: 10.1016/j.carbpol.2014.06.073
Abstract: We have developed a low-toxicity bioadhesive based on oxidized dextran and poly-L-lysine. Here, we report that the mechanical properties and degradation of this novel hydrogel bioadhesive can be controlled by changing the extent of oxidation of the dextran and the type or concentration of the anhydride species in the acylated poly-L-lysine. The dynamic moduli of the hydrogels can be controlled from 120 Pa to 20 kPa, suggesting that they would have mechanical compatibility with various tissues, and could have applications as tissue adhesives. Development of the hydrogel color from clear to brown indicates that the reaction between the dextran aldehyde groups and the poly-L-lysine amino groups may be induced by a Maillard reaction via Schiff base formation. Degradation of the aldehyde dextran may begin by reaction of the amino groups in the poly-L-lysine. The gel degradation can be ascribed to degradation of the aldehyde dextran in the hydrogel, although the aldehyde dextran itself is relatively stable in water. The oxidized dextran and poly-L-lysine, and the degraded hydrogel showed low cytotoxicities. These findings indicate that a hydrogel consisting of oxidized dextran and poly-L-lysine has low toxicity and a well-controlled degradation rate, and has potential clinical applications as a bioadhesive.
Rights: Copyright (C)2014, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license (CC BY-NC-ND 4.0). [http://creativecommons.org/licenses/by-nc-nd/4.0/] NOTICE: This is the author's version of a work accepted for publication by Elsevier. Kazuaki Matsumura, Naoki Nakajima, Hajime Sugai, Suong-Hyu Hyon, Carbohydrate Polymers, 113, 2014, 32-38, http://dx.doi.org/10.1016/j.carbpol.2014.06.073
URI: http://hdl.handle.net/10119/12846
Material Type: author
Appears in Collections:c10-1. 雑誌掲載論文 (Journal Articles)

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