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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/14724

Title: 両性電解質高分子ハイドロゲルによる細胞のカプセル化と凍結
Authors: 松村, 和明
Keywords: Cryopreservation
Regenerative medicine
Issue Date: 2013-10-15
Publisher: 低温生物工学会
Magazine name: 低温生物工学会誌 = Cryobiology and cryotechnology
Volume: 59
Number: 2
Start page: 111
End page: 115
DOI: 10.20585/cryobolcryotechnol.59.2_111
Abstract: Recently we showed that carboxylated poly-L-lysine, which is classified as a polyampholyte, has a cryoprotective effect on cells in solution without any other cryoprotectants. The recent study suggests that extra cellular environment might affect the cell viability after cryopreservation. Cryopreservation of cell-containing constructs is in high demand in tissue-engineering applications to produce the tissue-engineered products "off-the-shelf". However, cryopreservation of regenerated tissues including cell sheets and cell constructions is not easy compared to cell suspensions. In this study, we attempted to make cell scaffolds using polyampholytes for the development of the novel cryoprotective cell hydrogel scaffolds. Cells encapsulated with such in situ hydrogels can be cryopreserved well without addition of any cryoprotectants. Thus, these hydrogels can serve as scaffolds with cryoprotective properties that also provide structural integrity to tissue constructs.
Rights: Copyright (C) 2013 低温生物工学会. 松村 和明, 低温生物工学会誌 = Cryobiology and cryotechnology, 59(2), 2013, 111-115. http://dx.doi.org/10.20585/cryobolcryotechnol.59.2_111
URI: http://hdl.handle.net/10119/14724
Material Type: publisher
Appears in Collections:c10-1. 雑誌掲載論文 (Journal Articles)

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