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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/14726

Title: Preparation of novel synthetic cryoprotectants
Authors: Rajan, Robin
Matsumura, Kazuaki
Keywords: Polyampholytes
Cryoprotectant
Synthetic polymer
両性電解質高分子
凍結保護物質
合成高分子
Issue Date: 2014-10-15
Publisher: 低温生物工学会
Magazine name: 低温生物工学会誌 = Cryobiology and cryotechnology
Volume: 60
Number: 2
Start page: 99
End page: 103
DOI: 10.20585/cryobolcryotechnol.60.2_99
Abstract: We developed various novel synthetic polyampholytes via reversible addition fragmentation chain transfer (RAFT) polymerization for cryopreservation of cells. The polymers, in spite of being structurally analogous with each other, showed very different cryoprotective properties. Copolymer of methacrylic acid (MAA) and N, N-dimethylaminoethyl methacrylate (DMAEMA) showed excellent cryoprotective property and the hydrophobic modification of the copolymer enhanced the cell viability significantly. On the other hand, another polymer with similar structure, poly-carboxymethyl betaine (poly-CMB), a zwitterion-type polyampholyte, exhibited no cryoprotective property and the addition of hydrophobicity did not have much effect on the cell viability, whereas a similar zwitterion type polyampholyte, poly-sulfobetaine (poly-SPB), exhibited intermediate cryoprotective property. These findings suggest that cryoprotective property depends to a great extent on the polymer structure and the structural differences affect the interaction among polymer chains in solution.
Rights: Copyright (C) 2014 低温生物工学会. Robin Rajan, Kazuaki Matsumura, 低温生物工学会誌 = Cryobiology and cryotechnology, 60(2), 2014, 99-103. http://dx.doi.org/10.20585/cryobolcryotechnol.60.2_99
URI: http://hdl.handle.net/10119/14726
Material Type: author
Appears in Collections:c10-1. 雑誌掲載論文 (Journal Articles)

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