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このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/10119/14726

タイトル: Preparation of novel synthetic cryoprotectants
著者: Rajan, Robin
Matsumura, Kazuaki
キーワード: Polyampholytes
Synthetic polymer
発行日: 2014-10-15
出版者: 低温生物工学会
誌名: 低温生物工学会誌 = Cryobiology and cryotechnology
巻: 60
号: 2
開始ページ: 99
終了ページ: 103
DOI: 10.20585/cryobolcryotechnol.60.2_99
抄録: We developed various novel synthetic polyampholytes via reversible addition fragmentation chain transfer (RAFT) polymerization for cryopreservation of cells. The polymers, in spite of being structurally analogous with each other, showed very different cryoprotective properties. Copolymer of methacrylic acid (MAA) and N, N-dimethylaminoethyl methacrylate (DMAEMA) showed excellent cryoprotective property and the hydrophobic modification of the copolymer enhanced the cell viability significantly. On the other hand, another polymer with similar structure, poly-carboxymethyl betaine (poly-CMB), a zwitterion-type polyampholyte, exhibited no cryoprotective property and the addition of hydrophobicity did not have much effect on the cell viability, whereas a similar zwitterion type polyampholyte, poly-sulfobetaine (poly-SPB), exhibited intermediate cryoprotective property. These findings suggest that cryoprotective property depends to a great extent on the polymer structure and the structural differences affect the interaction among polymer chains in solution.
Rights: Copyright (C) 2014 低温生物工学会. Robin Rajan, Kazuaki Matsumura, 低温生物工学会誌 = Cryobiology and cryotechnology, 60(2), 2014, 99-103. http://dx.doi.org/10.20585/cryobolcryotechnol.60.2_99
URI: http://hdl.handle.net/10119/14726
資料タイプ: author
出現コレクション:c10-1. 雑誌掲載論文 (Journal Articles)


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