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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/14786

Title: Tunable Dual-Thermoresponsive Core–Shell Nanogels Exhibiting UCST and LCST Behavior
Authors: Rajan, Robin
Matsumura, Kazuaki
Issue Date: 2017-09-27
Publisher: WILEY-VCH Verlag GmbH & Co.
Magazine name: Macromolecular Rapid Communications
Volume: 38
Number: 22
Start page: 1700478
DOI: 10.1002/marc.201700478
Abstract: Thermoresponsive polymers change their physical properties as the temperature is changed and have found extensive use in a number of fields, especially in tissue engineering and in the development of drug delivery systems. The synthesis of a novel core–shell nanogel composed of N-isopropylacrylamide and sulfobetaine by reversible addition fragmentation chain transfer polymerization is reported. The core–shell architecture of the nanogels is confirmed using energy dispersive X-ray spectroscopy in scanning transmission electron microscopy. These nanogels exhibit dual thermoresponsive behavior, i.e., the core of the nanogel exhibits lower critical solution temperature, while the shell displays upper critical solution temperature behavior. Transition temperatures can be easily tuned by changing the molecular weight of the constituent polymer. These nanogels can be efficiently used in temperature-triggered delivery of therapeutic proteins and drugs.
Rights: Copyright (C) 2017 WILEY-VCH Verlag GmbH & Co. This article is an open access article. Robin Rajan, Kazuaki Matsumura, Macromolecular Rapid Communications, 38(22), 2017, 1700478. DOI:10.1002/marc.201700478. http://dx.doi.org/10.1002/marc.201700478
URI: http://hdl.handle.net/10119/14786
Material Type: publisher
Appears in Collections:c10-1. 雑誌掲載論文 (Journal Articles)

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