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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/15285

Title: Switchable release nano-reservoirs for co-delivery of drugs via a facile micelle-hydrogel composite
Authors: Patel, Monika
Kaneko, Tatsuo
Matsumura, Kazuaki
Keywords: drug delivery
dual delivery
Issue Date: 2017-04-12
Publisher: Royal Society of Chemistry
Magazine name: Journal of Materials Chemistry B
Volume: 5
Number: 19
Start page: 3488
End page: 3497
DOI: 10.1039/C7TB00701A
Abstract: Precise and controlled drug delivery systems are required to facilitate effective therapeutics. To address this need, we devised a micelle-hydrogel composite based on amphiphilic polypeptides as a general carrier model for the switchable and controlled release of dual drugs. Two different di-block polypeptides, poly (L-lysine-b-L- phenylalanine) and poly (L-glutamic acid-b-L-phenylalanine) (PGA-PPA), were synthesized to form distinct self-assembling micellar systems that were loaded with curcumin and amphotericin B, respectively, as model drugs. The drug-loaded micellar mixture was crosslinked utilizing the pendant amino groups of the L-lysine side chains via genipin to yield a micelle-hydrogel composite with PGA-PPA micelles trapped in the interlinked hydrogel system. This composite allowed for controlled multiphasic drug release and could be effectively tuned to moderate the pace and amount of drug release and be easily regulated to switch the drug release kinetics over a range of simple factors such as change in pH, cross-linking density, and composition.
Rights: Copyright (C) 2017 Royal Society of Chemistry. Monika Patel, Tatsuo Kaneko and Kazuaki Matsumura, Journal of Materials Chemistry B, 5(19), 2017, 3488-3497. http://dx.doi.org/10.1039/C7TB00701A - Reproduced by permission of The Royal Society of Chemistry
URI: http://hdl.handle.net/10119/15285
Material Type: author
Appears in Collections:c10-1. 雑誌掲載論文 (Journal Articles)

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