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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/15290

Title: Facile preparation of transparent poly(vinyl alcohol) hydrogels with uniform microcrystalline structure by hot pressing without using organic solvents
Authors: Sakaguchi, Tomoyo
Nagano, Shusaku
Hara, Mitsuo
Hyon, Suong-Hyu
Patel, Monika
Matsumura, Kazuaki
Keywords: biomaterials
crystallization
PVA
hydrogel
artificial cartilage
Issue Date: 2017-04-05
Publisher: Springer Nature
Magazine name: Polymer Journal
Volume: 49
Start page: 535
End page: 542
DOI: 10.1038/pj.2017.18
Abstract: Poly(vinyl alcohol) hydrogels (PVA-Hs) are promising materials for various biomedical applications and have been studied extensively. Low-temperature crystallization is the most popular method used to prepare PVA-Hs with excellent mechanical properties. However, this method uses DMSO as a solvent, which is toxic and difficult to handle. In this study, a novel hot pressing method was developed for preparing transparent PVA-Hs in order to eliminate the need of DMSO for solubilizing PVA during gelation. Unlike the conventional methods, this method used high initial concentrations of PVA, which made the molding of the gels easy and enhanced their gelation. The hydrogels prepared by hot pressing showed rapid gelation of the PVA molecules along with an enhanced crystallinity, unlike the hydrogels prepared by freezing and thawing. The efficiency of different solvents (water and DMSO/water mixtures) for the preparation of PVA-Hs by the hot pressing method was tested. The total amount of crystallites was the same for all the gels irrespective of the solvent used. However, the gels solubilized in only water showed a decrease in the net crystal size. This method not only eliminates the use of DMSO in preparing PVA-Hs but also produces gels with high mechanical properties for future use.
Rights: This is the author's version of the work. Copyright (C) 2017 Springer Nature. Tomoyo Sakaguchi, Shusaku Nagano, Mitsuo Hara, Suong-Hyu Hyon, Monika Patel, Kazuaki Matsumura, Polymer Journal, 49, 2017, 535-542. http://dx.doi.org/10.1038/pj.2017.18
URI: http://hdl.handle.net/10119/15290
Material Type: author
Appears in Collections:c10-1. 雑誌掲載論文 (Journal Articles)

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