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このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/10119/15439

タイトル: Controlling the degradation of an oxidized dextran-based hydrogel independent of the mechanical properties
著者: Nonsuwan, Punnida
Matsugami, Akimasa
Hayashi, Fumiaki
Hyon, Suong-Hyu
Matsumura, Kazuaki
キーワード: Hydrogel
Aldehyde dextran
Drug delivery
発行日: 2018-10-03
出版者: Elsevier
誌名: Carbohydrate Polymers
巻: 204
開始ページ: 131
終了ページ: 141
DOI: 10.1016/j.carbpol.2018.09.081
抄録: The objective of this study is to control and elucidate the mechanism of molecular degradation in a polysaccharide hydrogel. Glycidyl methacrylate (GMA) immobilized dextran (Dex-GMA) was oxidized by periodate to introduce aldehyde groups (oxidized Dex-GMA). The hydrogel was formed by the addition of dithiothreitol to the oxidized Dex-GMA solution through thiol Michael addition with the preservation of the aldehyde group for degradation points. It was experimentally determined that the degradation of this hydrogel can be controlled by the addition of amino groups and the speed of degradation can be controlled independently of mechanical properties because crosslinking and degradation points are different. In addition, the molecular mechanism of the crosslinking between the thiol and aldehyde groups was found to control the degradation of dextran derivatives. It is expected that these results will be beneficial in the design of polymer materials in which the speed of degradation can be precisely controlled. In addition, the cytotoxicity of oxidized Dex-GMA was approximately 3000 times lower than that of glutaraldehyde. The low cytotoxicity of the aldehyde in oxidized Dex-GMA was the likely reason for the harmless functionalized polysaccharide material. Possible future clinical applications include cell scaffolds in regenerative medicine and carriers for drug delivery systems.
Rights: (c) 2018 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/). Punnida Nonsuwan, Akimasa Matsugami, Fumiaki Hayashi, Suong-Hyu Hyon, Kazuaki Matsumura, Carbohydrate Polymers, 204, 2018, 131-141. DOI:10.1016/j.carbpol.2018.09.081
URI: http://hdl.handle.net/10119/15439
資料タイプ: publisher
出現コレクション:c10-1. 雑誌掲載論文 (Journal Articles)


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