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このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/10119/15508

タイトル: Development and Characterization of a Poly Vinyl Alcohol)/Graphene Oxide Composite Hydrogel as An Artificial Cartilage Material
著者: Zhao, Yibo
Terai, Wataru
Hoshijima, Yuko
Gotoh, Kazuma
Matsuura, Koji
Matsumura, Kazuaki
キーワード: PVA
graphene oxide
composite hydrogel
発行日: 2018-11-16
出版者: MDPI
誌名: Applied Sciences
巻: 8
号: 11
開始ページ: 2272
DOI: 10.3390/app8112272
抄録: Poly (vinyl alcohol) hydrogel (PVA-H) is expected to be a suitable artificial articular cartilage material because of its high biocompatibility. However, it is difficult to affix to the surface of a living joint because it is bioinert and its mechanical strength needs to be improved. In this study, graphene oxide (GO) subjected to two oxidation rounds was used to form a nanocomposite material and the composite hydrogel PVA-GO-H was prepared by low-temperature crystallization. Scanning electron microscope (SEM) images showed that the addition of GO can increase roughness of the hydrogel surface. Contact angle measurements showed that the surface of PVA-GO-H exhibited hydrophobicity that increased with GO concentration and not with that of PVA-H, indicating that the hydrophilic parts of PVA and GO form hydrogen bonds and the hydrophobic part of GO was exposed on the surface. Tensile tests demonstrated that Young’s modulus was enhanced on the addition of GO. Osteoblast cells showed more affinity for PVA-GO-H than PVA-H, which much more cells adhere to than to PVA-GO-H after a certain period of culturing, suggesting GO can improve the cell attachment of PVA-H. Further studies on the influence of the oxidation time of GO are still required.
Rights: (c) 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Yibo Zhao, Wataru Terai, Yuko Hoshijima, Kazuma Gotoh, Koji Matsuura, and Kazuaki Matsumura, Applied Sciences, 8(11), 2018, 2272. DOI:10.3390/app8112272
URI: http://hdl.handle.net/10119/15508
資料タイプ: publisher
出現コレクション:c10-1. 雑誌掲載論文 (Journal Articles)


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