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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/15876

Title: Hydrophobic Polyampholytes and Nonfreezing Cold Temperature Stimulate Internalization of Au Nanoparticles to Zwitterionic Liposomes
Authors: Ahmed, Sana
Matsumura, Kazuaki
Hamada, Tsutomu
Keywords: Nanoparticle internalization
Hydrophobic polyampholytes
Cold temperature
Cell-sized liposomes
Issue Date: 2018-06-24
Publisher: American Chemical Society
Magazine name: Langmuir
Volume: 35
Number: 5
Start page: 1740
End page: 1748
DOI: 10.1021/acs.langmuir.8b00920
Abstract: Nanomedicine relies on the effective internalization of nanoparticles combined with polymeric nanocarriers into living cells. Thus, exploration of internalization is essential for improving the efficacy of nanoparticle-based strategies in clinical practice. Here, we investigated the physicochemical internalization of gold nanoparticles (AuNPs) conjugated with hydrophobic polyampholytes into cell-sized liposomes at a low but non-frozen temperature. The hydrophobic polyampholytes localized in the disordered phase of the membrane, and internalization of AuNPs was enhanced in the presence of hydrophobic polyampholytes together with incubation at −3 °C as compared to 25 °C. These results contribute toward a mechanistic understanding for developing a model nanomaterials-driven delivery system based on hydrophobic polyampholytes and low temperature.
Rights: Sana Ahmed, Kazuaki Matsumura, and Tsutomu Hamada, Langmuir, 2018, 35(5), pp.1740-1748. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright (c) American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.langmuir.8b00920.
URI: http://hdl.handle.net/10119/15876
Material Type: author
Appears in Collections:c10-1. 雑誌掲載論文 (Journal Articles)

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