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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/15876

Title: Hydrophobic Polyampholytes and Nonfreezing Cold Temperature Stimulate Internalization of Au Nanoparticles to Zwitterionic Liposomes
Authors: Ahmed, Sana
Matsumura, Kazuaki
Hamada, Tsutomu
Keywords: Nanoparticle internalization
Hydrophobic polyampholytes
Cold temperature
Cell-sized liposomes
Issue Date: 2018-06-24
Publisher: American Chemical Society
Magazine name: Langmuir
Volume: 35
Number: 5
Start page: 1740
End page: 1748
DOI: 10.1021/acs.langmuir.8b00920
Abstract: Nanomedicine relies on the effective internalization of nanoparticles combined with polymeric nanocarriers into living cells. Thus, exploration of internalization is essential for improving the efficacy of nanoparticle-based strategies in clinical practice. Here, we investigated the physicochemical internalization of gold nanoparticles (AuNPs) conjugated with hydrophobic polyampholytes into cell-sized liposomes at a low but non-frozen temperature. The hydrophobic polyampholytes localized in the disordered phase of the membrane, and internalization of AuNPs was enhanced in the presence of hydrophobic polyampholytes together with incubation at −3 °C as compared to 25 °C. These results contribute toward a mechanistic understanding for developing a model nanomaterials-driven delivery system based on hydrophobic polyampholytes and low temperature.
Rights: Sana Ahmed, Kazuaki Matsumura, and Tsutomu Hamada, Langmuir, 2018, 35(5), pp.1740-1748. This document is the author's version of a work that was subsequently accepted for publication in Langmuir, copyright (c) American Chemical Society after peer review. To access the final edited and published work, see http://dx.doi.org/10.1021/acs.langmuir.8b00920
URI: http://hdl.handle.net/10119/15876
Material Type: author
Appears in Collections:c10-1. 雑誌掲載論文 (Journal Articles)

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