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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/16674

Title: Amino-Carrageenan@Polydopamine Microcomposites as Initiators for the Degradation of Hydrogel by near-Infrared Irradiation for Controlled Drug Release
Authors: Nonsuwan, Punnida
Matsumura, Kazuaki
Keywords: carrageenan derivative
temperature-sensitive material
NIR irradiation
hydrogel
degradation
Issue Date: 2019-01-09
Publisher: American Chemical Society
Magazine name: ACS Applied Polymer Materials
Volume: 1
Number: 2
Start page: 289
End page: 297
DOI: 10.1021/acsapm.8b00209
Abstract: A hydrogel immobilized with light-responsive amino group was developed by using amino-kappa carrageenan (amino-CG) and polydopamine (PDA). In the hybrid amino-CG@PDA microcomposite system, amino-CG was used to encapsulate PDA microspheres that act as a photothermal agent. Near infrared (NIR) irradiation is absorbed by the PDA to generate heat, releasing the amino-CG via gel-to-sol phase transition. By precisely controlling the transition temperature of amino-CG gel at 40 °C by adding a KCl hardening solution at the appropriate concentration, we successfully developed a composite hydrogel that dissolves at 40 °C when heated with NIR irradiation. The amino-CG@PDA was further composited into an aldehyde-introduced dextran hydrogel, which was reported to degrade by reaction with amino compounds. Utilizing the amino-CG release via NIR irradiation, we can successfully control the release of drug incorporated in the hydrogel, in which the NIR irradiation helps to diffuse amino-CG into the dextran hydrogel to initiate the hydrogel degradation by the reaction with aldehyde.
Rights: Punnida Nonsuwan and Kazuaki Matsumura, ACS Applied Polymer Materials, 1(2), pp.289-297. This document is the unedited author's version of a work that was subsequently accepted for publication in ACS Applied Polymer Materials, copyright (c) American Chemical Society after peer review. To access the final edited and published work, see https://doi.org/10.1021/acsapm.8b00209
URI: http://hdl.handle.net/10119/16674
Material Type: author
Appears in Collections:c10-1. 雑誌掲載論文 (Journal Articles)

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