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このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10119/16674
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| タイトル: | Amino-Carrageenan@Polydopamine Microcomposites as Initiators for the Degradation of Hydrogel by near-Infrared Irradiation for Controlled Drug Release |
| 著者: | Nonsuwan, Punnida
Matsumura, Kazuaki |
| キーワード: | carrageenan derivative
temperature-sensitive material
NIR irradiation
hydrogel
degradation |
| 発行日: | 2019-01-09 |
| 出版者: | American Chemical Society |
| 誌名: | ACS Applied Polymer Materials |
| 巻: | 1 |
| 号: | 2 |
| 開始ページ: | 289 |
| 終了ページ: | 297 |
| DOI: | 10.1021/acsapm.8b00209 |
| 抄録: | A hydrogel immobilized with light-responsive amino group was developed by using amino-kappa carrageenan (amino-CG) and polydopamine (PDA). In the hybrid amino-CG@PDA microcomposite system, amino-CG was used to encapsulate PDA microspheres that act as a photothermal agent. Near infrared (NIR) irradiation is absorbed by the PDA to generate heat, releasing the amino-CG via gel-to-sol phase transition. By precisely controlling the transition temperature of amino-CG gel at 40 °C by adding a KCl hardening solution at the appropriate concentration, we successfully developed a composite hydrogel that dissolves at 40 °C when heated with NIR irradiation. The amino-CG@PDA was further composited into an aldehyde-introduced dextran hydrogel, which was reported to degrade by reaction with amino compounds. Utilizing the amino-CG release via NIR irradiation, we can successfully control the release of drug incorporated in the hydrogel, in which the NIR irradiation helps to diffuse amino-CG into the dextran hydrogel to initiate the hydrogel degradation by the reaction with aldehyde. |
| Rights: | Punnida Nonsuwan and Kazuaki Matsumura, ACS Applied Polymer Materials, 1(2), pp.289-297. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Polymer Materials, copyright (c) American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsapm.8b00209. |
| URI: | http://hdl.handle.net/10119/16674 |
| 資料タイプ: | author |
| 出現コレクション: | c10-1. 雑誌掲載論文 (Journal Articles)
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このアイテムのファイル:
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| 3125.pdf | | 1687Kb | Adobe PDF | 見る/開く |
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