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このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10119/17043
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| タイトル: | Effect of dual‐drug‐releasing micelle–hydrogel composite on wound healing in vivo in full‐thickness excision wound rat model |
| 著者: | Patel, Monika
Nakaji‐Hirabayashi, Tadashi
Matsumura, Kazuaki |
| キーワード: | Micelle-hydrogel composite
dermal wound healing
pH-sensitive release
dual-drug release
polypeptide hydrogel |
| 発行日: | 2019-01-31 |
| 出版者: | Wiley |
| 誌名: | Journal of Biomedical Materials Research Part A |
| 巻: | 107 |
| 号: | 5 |
| 開始ページ: | 1094 |
| 終了ページ: | 1106 |
| DOI: | 10.1002/jbm.a.36639 |
| 抄録: | Wound healing is a complex process involving an intricate cascade of body responses. A composite dressing that would effectively target different stages of wound healing and regeneration is urgently needed. In the current study, we tested the efficacy of a previously prepared micelle-hydrogel composite loaded with two drugs, in full-thickness excision wound model in rat. We found that the composite elicited almost no inflammation and effectively enhanced healing at all stages of the healing process. An initial burst of the first drug, amphotericin B, eliminated any preliminary infection. This burst was followed by a gradual release of curcumin as the healing and anti-inflammatory agent. Better healing was observed in rats treated with the drug-loaded composites than in blank and control groups. Wounds showed up to 80% closure in the treated group, with high collagen deposition. Re-epithelialization and granulation were also better in the treated group than in the non-treated control and blank groups. Histopathological examination revealed that drug-loaded composites improved cutaneous wound healing and regeneration. In conclusion, the micelle-hydrogel composite is an effective dressing and might have major applications in wound healing. |
| Rights: | (c) 2019 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Monika Patel, Tadashi Nakaji‐Hirabayashi, Kazuaki Matsumura, Journal of Biomedical Materials Research Part A, 107(5), 2019, 1094-1106, which has been published in final form at https://doi.org/10.1002/jbm.a.36639. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| URI: | http://hdl.handle.net/10119/17043 |
| 資料タイプ: | author |
| 出現コレクション: | c10-1. 雑誌掲載論文 (Journal Articles)
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