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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/17579

Title: Low cytotoxic tissue adhesive based on oxidized dextran and epsilon-poly-L-lysine
Authors: Hyon, Suong-Hyu
Nakajima, Naoki
Sugai, Hajime
Matsumura, Kazuaki
Keywords: dextran
Issue Date: 2013-08-30
Publisher: Wiley
Magazine name: Journal of Biomedical Materials Research Part A
Volume: 102
Number: 8
Start page: 2511
End page: 2520
DOI: 10.1002/jbm.a.34923
Abstract: A novel adhesive hydrogel consisting of dextran and epsilon-poly(L-lysine) (dextran-PL) with multiple biomedical applications was developed. Periodate oxidation in aqueous media almost stoichiometrically introduces aldehyde groups in dextran molecules, and aldehyde dextran can react with the primary amino groups in epsilon-PL (ɛ-PL) at neutral pH to form a hydrogel. The gelation time of the hydrogel can be easily controlled by the extent of oxidation in dextran and of the acylation in ɛ-PL by anhydrides. The shear adhesion strength of dextran-PL was 10 times higher than that of fibrin glue, when wet collagen sheets were selected as test specimens. The cytotoxicity of aldehyde dextran and ɛ-PL were 1000 times lower than that of glutaraldehyde and poly(allylamine). The considerably low cytotoxicity of aldehyde dextran could be ascribed to its low reactivity with amine species when compared with glutaraldehyde. In contrast, a high reactivity of amino groups in ɛ-PL was observed when compared with glycine, L-lysine, and gelatin, which could be explained by their poor dissociation at neutral pH, thus leading to low cytotoxicity.
Rights: (c) 2013 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Suong-Hyu Hyon, Naoki Nakajima, Hajime Sugai, Kazuaki Matsumura, Journal of Biomedical Materials Research Part A, 102(8), 2013, 2511-2520, which has been published in final form at https://doi.org/10.1002/jbm.a.34923. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
URI: http://hdl.handle.net/10119/17579
Material Type: author
Appears in Collections:c10-1. 雑誌掲載論文 (Journal Articles)

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