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このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10119/18767
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| タイトル: | Elucidating the degradation mechanism of a self-degradable dextran-based medical adhesive |
| 著者: | Hyon, Woogi
Shibata, Shuji
Ozaki, Etsuo
Fujimura, Motoki
Hyon, Suong-Hyu
Matsumura, Kazuaki |
| キーワード: | hydrogel
LYDEX
degradation
dextran
poly-L-lysine
Maillard reaction |
| 発行日: | 2021-12-03 |
| 出版者: | Elsevier |
| 誌名: | Carbohydrate Polymers |
| 巻: | 278 |
| 開始ページ: | 118949 |
| DOI: | 10.1016/j.carbpol.2021.118949 |
| 抄録: | We developed a self-degradable medical adhesive, LYDEX, consisting of periodate-oxidized aldehyde-functionalized dextran (AD) and succinic anhydride-treated ε-poly-L-lysine (SAPL). After gelation and adhesion of LYDEX by Schiff base bond formation between the AD aldehyde groups and SAPL amino groups, molecular degradation associated with the Maillard reaction is initiated, but the detailed degradation mechanism remains unknown. Herein, we elucidated the degradation mechanism of LYDEX by analyzing the main degradation products under typical solution conditions in vitro. The degradation of the LYDEX gel with a sodium periodate/dextran content of 2.5/20 was observed using gel permeation chromatography and infrared and 1H NMR spectroscopy. The AD ratio in the AD-SAPL mixture increased as the molecular weight decreased with the degradation time. This discovery of LYDEX self-degradability is useful for clarifying other polysaccharide hydrogel degradation mechanisms, and valuable for the use of LYDEX in medical applications, such as hemostatic or sealant materials. |
| Rights: | Copyright (C) 2021, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license (CC BY-NC-ND 4.0). [http://creativecommons.org/licenses/by-nc-nd/4.0/] NOTICE: This is the author's version of a work accepted for publication by Elsevier. Woogi Hyon, Shuji Shibata, Etsuo Ozaki, Motoki Fujimura, Suong-Hyu Hyon, Kazuaki Matsumura, Carbohydrate Polymers, 278, 2021, 118949, https://doi.org/10.1016/j.carbpol.2021.118949 |
| URI: | http://hdl.handle.net/10119/18767 |
| 資料タイプ: | author |
| 出現コレクション: | c10-1. 雑誌掲載論文 (Journal Articles)
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このアイテムのファイル:
| ファイル |
記述 |
サイズ | 形式 |
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| K-MATSUMURA-M-1101-1.pdf | 本文 | 1720Kb | Adobe PDF | 見る/開く | | K-MATSUMURA-M-1101-2.pdf | 補足資料 | 549Kb | Adobe PDF | 見る/開く |
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