JAIST Repository >
School of Materials Science >
Articles >
Journal Articles >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/4932

Title: Enhanced Effects of Lithocholic Acid Incorporation into Liquid Crystalline Biopolymer Poly(Coumaric Acid) on Structural Ordering and Cell Adhesion
Authors: Matsusaki, Michiya
Tran, Hang Thi
Kaneko, Tatsuo
Akashi, Mitsuru
Issue Date: 2005-11
Publisher: Elsevier
Magazine name: Biomaterials
Volume: 26
Number: 32
Start page: 6263
End page: 6270
DOI: 10.1016/j.biomaterials.2005.03.044
Abstract: A novel thermotropic liquid crystalline biocopolymer, poly{4-hydroxycinnamic acid (4HCA: coumaric acid)-co-lithocholic acid (LCA)}, was synthesized by a thermal polycondensation of 4HCA and LCA. When the LCA molar composition of P(4HCA-co-LCA)) was 0, 5, 7, 23, 27, and 45 mol%, the copolymers showed a nematic liquid-crystalline phase. The melting point of the copolymers was 120-250 oC depending on the LCA composition, and showed a maximum at 7 mol%. Wide angle X-ray diffraction (WAXD) analysis showed a typical diffraction pattern of a hexagonal arrangement for 0, 7, 23, and 27 mol% LCA molar composition, which were cooled from a nematic melt. The other polymers showed no distinct diffraction. In particular, the copolymer of 7 mol% LCA molar composition showed four distinct diffractions corresponding to spacings with a reciprocal ratio of 1, 3^<0.5>, 2, and 7^<0.5>, indicating the highest structural ordering of all copolymers prepared here. The results of the cell adhesion and static contact angle tests suggest that the 7 mol% LCA molar composition copolymer had the highest hydrophobicity and cell adhesion ability, which was easily controlled by altering in feed. We conclude that the structural ordering may have a significant correlation with cell adhesion activity.
Rights: NOTICE: This is the author's version of a work accepted for publication by Elsevier. Michiya Matsusaki, Tran Hang Thi, Tatsuo Kaneko and Mitsuru Akashi, Biomaterials, 26(32), 2005, 6263-6270, http://dx.doi.org/10.1016/j.biomaterials.2005.03.044
URI: http://hdl.handle.net/10119/4932
Material Type: author
Appears in Collections:c10-1. 雑誌掲載論文 (Journal Articles)

Files in This Item:

File Description SizeFormat
125-15.pdf232KbAdobe PDFView/Open

All items in DSpace are protected by copyright, with all rights reserved.


Contact : Library Information Section, Japan Advanced Institute of Science and Technology