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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/8501

Title: Stress analysis in a layered aortic arch model under pulsatile blood flow
Authors: Gao, Feng
Watanabe, Masahiro
Matsuzawa, Teruo
Issue Date: 2006-04-24
Publisher: BioMed Central Ltd.
Magazine name: BioMedical Engineering OnLine
Volume: 5
Number: article no.25
DOI: 10.1186/1475-925X-5-25
Abstract: Background: Many cardiovascular diseases, such as aortic dissection, frequently occur on the aortic arch and fluid-structure interactions play an important role in the cardiovascular system. Mechanical stress is crucial in the functioning of the cardiovascular system; therefore, stress analysis is a useful tool for understanding vascular pathophysiology. The present study is concerned with the stress distribution in a layered aortic arch model with interaction between pulsatile flow and the wall of the blood vessel. Methods: A three-dimensional (3D) layered aortic arch model was constructed based on the aortic wall structure and arch shape. The complex mechanical interaction between pulsatile blood flow and wall dynamics in the aortic arch model was simulated by means of computational loose coupling fluid-structure interaction analyses. Results: The results showed the variations of mechanical stress along the outer wall of the arch during the cardiac cycle. Variations of circumferential stress are very similar to variations of pressure. Composite stress in the aortic wall plane is high at the ascending portion of the arch and along the top of the arch, and is higher in the media than in the intima and adventitia across the wall thickness. Conclusion: Our analysis indicates that circumferential stress in the aortic wall is directly associated with blood pressure, supporting the clinical importance of blood pressure control. High stress in the aortic wall could be a risk factor in aortic dissections. Our numerical layered aortic model may prove useful for biomechanical analyses and for studying the pathogeneses of aortic dissection.
Rights: BioMedical Engineering OnLine 2006, 5:25 doi:10.1186/1475-925X-5-25 This article is available from: http://www.biomedical-engineering-online.com/content/5/1/25 c 2006 Gao et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/10119/8501
Material Type: publisher
Appears in Collections:f10-1. 雑誌掲載論文 (Journal Articles)

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