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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/9524

Title: Manganese oxide nanoparticle-assisted laser desorption/ionization mass spectrometry for medical applications
Authors: Taira, Shu
Kitajima, Kenji
Katayanagi, Hikaru
Ichiishi, Eiichiro
Ichiyanagi, Yuko
Keywords: nano
metal oxide
transmission electron microscopy
ionization
mass spectrometry
Issue Date: 2009-07-14
Publisher: Institute of Physics and IOP Publishing Limited
Magazine name: Science and Technology of Advanced Materials
Volume: 10
Number: 3
Start page: 034602-1
End page: 034602-6
DOI: 10.1088/1468-6996/10/3/034602
Abstract: We prepared and characterized manganese oxide magnetic nanoparticles (d = 5.6 nm) and developed nanoparticle-assited laser desorption/ionization (nano-PALDI) mass spectrometry. The nanoparticles had MnO2 and Mn2O3 core conjugated with hydroxyl and amino groups、 and showed paramagnetism at room temperature. The nanoparticles worked as an ionization assistng reagent in mass spectroscopy. The mass spectra showed no background in the low m/z. The nanoparticles could ionize the samples of peptide、 drug and proteins (approx. 5、000 Da) without using matrix、 i.e. 2、5-dihydroxybenzoic acid (DHB)、 4-hydroxy-α-cinnamic acid (CHCA) and liquid matrix、 as conventional ionization assisting reagents. Post source decay spectra by nano-PALDI mass spectrometry will yield information of chemical structure of analyte.
Rights: Copyright (C) Institute of Physics and IOP Publishing Limited 2009. This is the author-created version of Institute of Physics and IOP Publishing Limited, Shu Taira, Kenji Kitajima, Hikaru Katayanagi, Eiichiro Ichiishi and Yuko Ichiyanagi, Science and Technology of Advanced Materials, 10(3), 2009, 034602-1-034602-6. http://dx.doi.org/10.1088/1468-6996/10/3/034602
URI: http://hdl.handle.net/10119/9524
Material Type: publisher
Appears in Collections:c10-1. 雑誌掲載論文 (Journal Articles)

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