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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/9554

Title: Model-Membrane Morphological Transformations Induced by Different Amyloid Molecular Assemblies
Authors: Morita, Masamune
Vestergaard, Mun'delanji
Hamada, Tsutomu
Takagi, Masahiro
Keywords: Amyloid beta
Alzheimer's disease
membrane
transformation
Issue Date: 2009
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Magazine name: International Symposium on Micro-NanoMechatronics and Human Science, 2009. MHS 2009
Start page: 220
End page: 224
DOI: 10.1109/MHS.2009.5352033
Abstract: Amyloid beta (Ab) has been strongly implicated in inducing neurotoxicity in the pathology of Alzheimer's disease (AD). However、 the underlying mechanisms remain unknown. In this study、 we examined、 in real-time、 the spatio-temporal changes in individual model membranes induced by the presence of different Ab-40 molecular assemblies (species). We used cell-sized lipid vesicles to enable the direct observation of these changes. We found two significantly different membrane-transformation pathways. We characterized the biophysical mechanisms behind these transformations in terms of the change in inner vesicle volume and surface area. Interestingly、 mature fibrils、 which are often considered inert species、 also induced profound membrane changes. The real-time observation of these morphological transformations、 which can be missed in a discretised analysis、 may help to unlock the mechanisms of Alzheimer's Ab-induced neuro-degeneration.
Rights: Copyright (C) 2009 IEEE. Reprinted from International Symposium on Micro-NanoMechatronics and Human Science, 2009. MHS 2009, 220-224. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of JAIST's products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to pubs-permissions@ieee.org. By choosing to view this document, you agree to all provisions of the copyright laws protecting it.
URI: http://hdl.handle.net/10119/9554
Material Type: publisher
Appears in Collections:c11-1. 会議発表論文 (Conference Papers)

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