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このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10119/9875
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| タイトル: | Photochemical control of membrane raft organization |
| 著者: | Hamada, Tsutomu
Sugimoto, Ryoko
Nagasaki, Takeshi
Takagi, Masahiro |
| キーワード: | raft
membrane
photo control
phase separation
azobenzene |
| 発行日: | 2011 |
| 出版者: | Royal Society of Chemistry |
| 誌名: | Soft Matter |
| 巻: | 7 |
| 開始ページ: | 220 |
| 終了ページ: | 224 |
| DOI: | 10.1039/C0SM00797H |
| 抄録: | Controllable membrane phase separation through the action of a synthetic photoresponsive amphiphile is reported. We studied multi-component giant vesicles formed from a ternary lipid mixture of saturated and unsaturated phospholipid and cholesterol together with the photoresponsive amphiphile. A change in the conformation of the photoresponsive amphiphile can switch membrane lateral segregation in a reversible manner. Cis-isomerization induces lateral phase separation in one-phase membranes or produces additional lateral domains in two-phase membranes. Membranes that are close to miscibility boundary show high photo-responsiveness. This is the first report on the reversible control of membrane lateral segregation triggered by a conformational change in a membrane-constituting molecule. These findings may lead to new methods for controlling membrane self-organization such as raft engineering. |
| Rights: | Copyright (C) 2011 Royal Society of Chemistry. Tsutomu Hamada, Ryoko Sugimoto, Takeshi Nagasaki, and Masahiro Takagi, Soft Matter, 7, 2011, 220-224. http://dx.doi.org/10.1039/C0SM00797H - Reproduced by permission of The Royal Society of Chemistry |
| URI: | http://hdl.handle.net/10119/9875 |
| 資料タイプ: | author |
| 出現コレクション: | c10-1. 雑誌掲載論文 (Journal Articles)
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