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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/9875

Title: Photochemical control of membrane raft organization
Authors: Hamada, Tsutomu
Sugimoto, Ryoko
Nagasaki, Takeshi
Takagi, Masahiro
Keywords: raft
photo control
phase separation
Issue Date: 2011
Publisher: Royal Society of Chemistry
Magazine name: Soft Matter
Volume: 7
Start page: 220
End page: 224
DOI: 10.1039/C0SM00797H
Abstract: Controllable membrane phase separation through the action of a synthetic photoresponsive amphiphile is reported. We studied multi-component giant vesicles formed from a ternary lipid mixture of saturated and unsaturated phospholipid and cholesterol together with the photoresponsive amphiphile. A change in the conformation of the photoresponsive amphiphile can switch membrane lateral segregation in a reversible manner. Cis-isomerization induces lateral phase separation in one-phase membranes or produces additional lateral domains in two-phase membranes. Membranes that are close to miscibility boundary show high photo-responsiveness. This is the first report on the reversible control of membrane lateral segregation triggered by a conformational change in a membrane-constituting molecule. These findings may lead to new methods for controlling membrane self-organization such as raft engineering.
Rights: Copyright (C) 2011 Royal Society of Chemistry. Tsutomu Hamada, Ryoko Sugimoto, Takeshi Nagasaki, and Masahiro Takagi, Soft Matter, 7, 2011, 220-224. http://dx.doi.org/10.1039/C0SM00797H - Reproduced by permission of The Royal Society of Chemistry
URI: http://hdl.handle.net/10119/9875
Material Type: author
Appears in Collections:c10-1. 雑誌掲載論文 (Journal Articles)

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