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https://hdl.handle.net/10119/9875
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| Title: | Photochemical control of membrane raft organization |
| Authors: | Hamada, Tsutomu
Sugimoto, Ryoko
Nagasaki, Takeshi
Takagi, Masahiro |
| Keywords: | raft
membrane
photo control
phase separation
azobenzene |
| Issue Date: | 2011 |
| Publisher: | Royal Society of Chemistry |
| Magazine name: | Soft Matter |
| Volume: | 7 |
| Start page: | 220 |
| End page: | 224 |
| DOI: | 10.1039/C0SM00797H |
| Abstract: | Controllable membrane phase separation through the action of a synthetic photoresponsive amphiphile is reported. We studied multi-component giant vesicles formed from a ternary lipid mixture of saturated and unsaturated phospholipid and cholesterol together with the photoresponsive amphiphile. A change in the conformation of the photoresponsive amphiphile can switch membrane lateral segregation in a reversible manner. Cis-isomerization induces lateral phase separation in one-phase membranes or produces additional lateral domains in two-phase membranes. Membranes that are close to miscibility boundary show high photo-responsiveness. This is the first report on the reversible control of membrane lateral segregation triggered by a conformational change in a membrane-constituting molecule. These findings may lead to new methods for controlling membrane self-organization such as raft engineering. |
| Rights: | Copyright (C) 2011 Royal Society of Chemistry. Tsutomu Hamada, Ryoko Sugimoto, Takeshi Nagasaki, and Masahiro Takagi, Soft Matter, 7, 2011, 220-224. http://dx.doi.org/10.1039/C0SM00797H - Reproduced by permission of The Royal Society of Chemistry |
| URI: | https://hdl.handle.net/10119/9875 |
| Material Type: | author |
| Appears in Collections: | c10-1. 雑誌掲載論文 (Journal Articles)
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| 15842-1.pdf | | 316Kb | Adobe PDF | View/Open |
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