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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/15286

Title: Lateral Tension-Induced Penetration of Particles into a Liposome
Authors: Shigyou, Kazuki
Nagai, Ken H.
Hamada, Tsutomu
Keywords: particle penetration
lateral tension
lipid membrane
gene delivery method
Issue Date: 2017-07-07
Publisher: MDPI
Magazine name: Materials
Volume: 10
Number: 7
Start page: 765
DOI: 10.3390/ma10070765
Abstract: It is important that we understand the mechanism of the penetration of particles into a living cell to achieve advances in bionanotechnology, such as for treatment, visualization within a cell, and genetic modification. Although there have been many studies on the application of functional particles to cells, the basic mechanism of penetration across a biological membrane is still poorly understood. Here we used a model membrane system to demonstrate that lateral membrane tension drives particle penetration across a lipid bilayer. After the application of osmotic pressure, fully wrapped particles on a liposome surface were found to enter the liposome. We discuss the mechanism of the tension-induced penetration in terms of narrow constriction of the membrane at the neck part. The present findings are expected to provide insight into the application of particles to biological systems.
Rights: Materials 2017, 10(7), 765; doi:10.3390/ma10070765 This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
URI: http://hdl.handle.net/10119/15286
Material Type: publisher
Appears in Collections:c10-1. 雑誌掲載論文 (Journal Articles)

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