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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/9890

Title: Sequence-dependent histone variant positioning signatures
Authors: Le, Ngoc Tu
Ho, Tu Bao
Ho, Bich Hai
Issue Date: 2010-12-02
Publisher: BioMed Central Ltd.
Magazine name: BMC Genomics
Volume: 11
Number: Suppl 4
Start page: S3
DOI: 10.1186/1471-2164-11-S4-S3
Abstract: Background: Nucleosome, the fundamental unit of chromatin, is formed by wrapping nearly 147bp of DNA around an octamer of histone proteins. This histone core has many variants that are different from each other by their biochemical compositions as well as biological functions. Although the deposition of histone variants onto chromatin has been implicated in many important biological processes, such as transcription and replication, themechanisms of how they are deposited on target sites are still obscure. Results: By analyzing genomic sequences of nucleosomes bearing different histone variants from human, including H2A.Z, H3.3 and both (H3.3/H2A.Z, so-called double variant histones), we found that genomic sequencecontributes in part to determining target sites for different histone variants. Moreover, dinucleotides CA/TG are remarkably important in distinguishing target sites of H2A.Z-only nucleosomes with those of H3.3-containing (both H3.3-only and double variant) nucleosomes. Conclusions: There exists a DNA-related mechanism regulating the deposition of different histone variants onto chromatin and biological outcomes thereof. This provides additional insights into epigenetic regulatory mechanisms of many important cellular processes.
Rights: © 2010 Le et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/10119/9890
Material Type: publisher
Appears in Collections:a11-1. 会議発表論文 (Conference Papers)

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