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Please use this identifier to cite or link to this item: http://hdl.handle.net/10119/11469

Title: Optimal Control of Boolean Biological Networks Modeled by Petri Nets
Authors: Kobayashi, Koichi
Hiraishi, Kunihiko
Keywords: asynchronous behavior
Boolean networks
integer programming
optimal control
Petri nets
Issue Date: 2013-02-01
Publisher: 電子情報通信学会
Magazine name: IEICE TRANSACTIONS on Fundamentals of Electronics, Communications and Computer Sciences
Volume: E96-A
Number: 2
Start page: 532
End page: 539
Abstract: A Boolean network model is one of the models of gene regulatory networks, and is widely used in analysis and control. Although a Boolean network is a class of discrete-time nonlinear systems and expresses the synchronous behavior, it is important to consider the asynchronous behavior. In this paper, using a Petri net, a new modeling method of asynchronous Boolean networks with control inputs is proposed. Furthermore, the optimal control problem of Petri nets expressing asynchronous Boolean networks is formulated, and is reduced to an integer programming problem. The proposed approach will provide us one of the mathematical bases of control methods for gene regulatory networks.
Rights: Copyright (C)2013 IEICE. Koichi Kobayashi and Kunihiko Hiraishi, IEICE TRANSACTIONS on Fundamentals of Electronics, Communications and Computer Sciences, E96-A(2), 2013, 532-539. http://www.ieice.org/jpn/trans_online/
URI: http://hdl.handle.net/10119/11469
Material Type: publisher
Appears in Collections:b10-1. 雑誌掲載論文 (Journal Articles)

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